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A fluorescent probe emitting in near-infrared region for sensitive and selective detection of biothiols in both solution and living cells.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Dec2015, Vol. 56 Issue 52, p7176-7179. 4p. - Publication Year :
- 2015
-
Abstract
- A fluorescent probe, 1,4-diethyl-7-(3-pyridin-2-yl-acroyloyl)-1,2,3,4-tetrahydro-5-oxa-1,4-diazaanthracen-6-one (probe 1 ), with an emission in near-infrared region was developed for sensitive and selective detection of biothiols. Probe 1 is essentially non-fluorescent due to the strong intramolecular charge transfer (ICT) from the electron-donating tetrahydroquinoxaline moiety to the electron-withdrawing pyridine group. Upon the treatment with biothiols, the conjugation system was broken via Michael addition reaction between biothiols and α,β-unsaturated ketone, which inhibited the ICT process and resulted in a remarkable fluorescence enhancement with an emission maximum at 660 nm. Moreover, probe 1 was successfully applied to image intracellular thiols in living cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 56
- Issue :
- 52
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 111440154
- Full Text :
- https://doi.org/10.1016/j.tetlet.2015.11.040