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Update on the Vitamin D and OmegA-3 trial (VITAL).
- Source :
-
Journal of Steroid Biochemistry & Molecular Biology . Jan2016 Part B, Vol. 155, p252-256. 5p. - Publication Year :
- 2016
-
Abstract
- Despite continued appreciation of the potential role of vitamin D and omega-3 fatty acids in the prevention of cancer and cardiovascular disease (CVD), there remain no completed large-scale, randomized trials of these agents for the primary prevention of cancer or CVD in a population that has not been selected on the basis of elevated risk. The VITamin D and OmegA-3 TriaL (VITAL) is a 2 × 2 factorial randomized, double-blind, placebo-controlled trial of the benefits and risks of vitamin D (vitamin D 3 [cholecalciferol], 2000 IU/d) and marine omega-3 fatty acids (Omacor ® fish oil, a 1 g/d) in the primary prevention of cancer and CVD among 25,875 men and women, aged ≥50 and ≥55 years, respectively. Randomization began in November 2011 and was completed in March 2014. This report will describe the rationale for the trial and currently available randomized trial data, summarize related ongoing large-scale trials, and provide a brief overview of study design, and an update on randomization milestones, racial/ethnic diversity, biorepository activities, in-depth phenotyping of a subcohort, and ancillary studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09600760
- Volume :
- 155
- Database :
- Academic Search Index
- Journal :
- Journal of Steroid Biochemistry & Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 111410099
- Full Text :
- https://doi.org/10.1016/j.jsbmb.2015.04.006