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Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.
- Source :
-
Cancer (0008543X) . Dec2015, Vol. 121 Issue 24, p4359-4368. 10p. - Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>Although colorectal mucinous adenocarcinomas (MCs) are conventionally regarded as exhibiting high-grade differentiation, they can be divided by differentiation into 2 groups according to the glandular appearance: low-grade mucinous adenocarcinoma (low-MC) and high-grade mucinous adenocarcinoma (high-MC). <bold>Methods: </bold>Patients with colorectal cancer (CRC) who underwent surgical resection between 2000 and 2012 were enrolled in this study. Among the cases with MC, the clinicopathological and genetic differences between low-MC and high-MC were investigated with next-generation sequencing. <bold>Results: </bold>A total of 1373 patients with CRC were analyzed. Forty patients (2.9%) had MC, and 13 patients had high-MC. Patients with MC had significantly shorter disease-free survival (DFS) and overall survival (OS) periods than those with nonmucinous carcinoma. When low-MC patients and high-MC patients were compared, those with high-MC had significantly shorter DFS and OS periods than those with low-MC. Multivariate analyses revealed that high-MC was significantly associated with both shorter DFS and shorter OS, but low-MC was not. A genome analysis revealed that low-MC had a considerably larger number of mutations than high-MC, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and adenomatous polyposis coli mutations were particularly frequently found in low-MC. In contrast, SMAD family member 4 (SMAD4) mutations were frequently found in high-MC. <bold>Conclusions: </bold>High-MC is an independent prognostic factor in CRC (but low-MC is not), and it is genetically different from other CRCs, including low-MC. Both the clinicopathological differences and the genetic differences suggest that low-MC and high-MC should be distinguished in clinical settings. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLON cancer
*MUCINOUS adenocarcinoma
*GENETIC mutation
*ADENOMATOUS polyposis coli
*NUCLEOTIDE sequencing
*PROTEIN metabolism
*CARRIER proteins
*COLON tumors
*POLYMERASE chain reaction
*PROGNOSIS
*PROTEINS
*TUMORS
*DNA-binding proteins
*RETROSPECTIVE studies
*NUCLEAR proteins
*SEQUENCE analysis
*TUMOR grading
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 121
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 111405528
- Full Text :
- https://doi.org/10.1002/cncr.29676