Two endoscopic submucosal dissection procedures for stripping huge segment of the gastric mucosa to treat early gastric signet ring cell carcinoma.

<bold>Aim: </bold>To introduce the method of stripping of early gastric signet ring cell carcinioma by two ESD procedures.<bold>Methods: </bold>A lesion of early gastric signet ring cell carcinoma in an elderly was removed by two consecutive ESD procedures. The pathology was analyzed and the patient was followed-up.<bold>Results: </bold>The lesion removed by first ESD procedure, which was 10 cm in diameter, has tumor tissue on its edge, and the second lesion which was 5 cm in diameter had an edge without tumor. There was no metastasis or recurrence during 24-month follow-up.<bold>Conclusion: </bold>We first described the method using two consecutive ESD procedures in man with gastric signet ring cell carcinoma, and the procedure was proved to be safe and efficient. [ABSTRACT FROM AUTHOR]