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The effect of TISSEEL fibrin sealant on seroma formation following complex abdominal wall hernia repair: a single institutional review and derived cost analysis.
- Source :
-
Hernia . Dec2015, Vol. 19 Issue 6, p935-942. 8p. - Publication Year :
- 2015
-
Abstract
- <bold>Purpose: </bold>The authors evaluated the ability of a fibrin sealant (TISSEELâ„¢: Baxter Healthcare Corp, Deerfield, IL, USA) to reduce the incidence of post-operative seroma following abdominal wall hernia repair.<bold>Methods: </bold>We performed a 4-year retrospective review of patients undergoing abdominal wall hernia repair, with and without TISSEEL, by a single surgeon (FEE) at The Johns Hopkins Hospital. Demographics, surgical risk factors, operative data and 30-day outcomes, including wound complications and related interventions, were compared. The quantity and cost of Tisseel per case was reviewed.<bold>Results: </bold>A total of 250 patients were evaluated: 127 in the TISSEEL group and 123 in the non-TISSEEL control group. The average age for both groups was 56.6 years (P = 0.97). The majority of patients were female (TISSEEL 52.8%, non-TISSEEL 56.1%, P = 0.59) and ASA Class III (TISSEEL 56.7%, non-TISSEEL 58.5%, P = 0.40). There was no difference in the average defect size for both groups (TISSEEL 217 ± 187.6 cm(2), non-TISSEEL 161.3 ± 141.5 cm(2), P = 0.36). Surgical site occurrences occurred in 18.1% of the TISSEEL and 13% of the non-TISSEEL group (P = 0.27). There was a trend towards an increased incidence of seroma in the TISSEEL group (TISSEEL 11%, non-TISSEEL 4.9%, P = 0.07). A total of $124,472.50 was spent on TISSEEL, at an average cost of $995.78 per case.<bold>Conclusions: </bold>In the largest study to date, TISSEELâ„¢ application offered no advantage for the reduction of post-operative seroma formation following complex abdominal hernia repair. Moreover, the use of this sealant was associated with significant costs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12654906
- Volume :
- 19
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Hernia
- Publication Type :
- Academic Journal
- Accession number :
- 111243396
- Full Text :
- https://doi.org/10.1007/s10029-015-1403-4