Back to Search
Start Over
Organometallic rhodium(iii) and iridium(iii) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands.
- Source :
-
Dalton Transactions: An International Journal of Inorganic Chemistry . 12/21/2015, Vol. 44 Issue 47, p20523-20531. 9p. - Publication Year :
- 2015
-
Abstract
- A series of half-sandwich cyclopentadienyl rhodium(iii) and iridium(iii) complexes of the type [Cp*M(curc/bdcurc)Cl] and [Cp*M(curc/bdcurc)(PTA)][SO3CF3], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O^O-chelating ligands, and PTA = 1,3,5-triaza-7-phosphaadamantane, is described. The X-ray crystal structures of three of the complexes, i.e. [Cp*Rh(curc)(PTA)][SO3CF3] (5), [Cp*Rh(bdcurc)(PTA)][SO3CF3] (6) and [Cp*Ir(bdcurc)(PTA)][SO3CF3] (8), confirm the expected “piano-stool” geometry. With the exception of 5, the complexes are stable under pseudo-physiological conditions and are moderately cytotoxic to human ovarian carcinoma (A2780 and A2780cisR) cells and also to non-tumorigenic human embryonic kidney (HEK293) cells, but lack the cancer cell selectivity observed for related arene ruthenium(ii) complexes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRIDIUM
*RHODIUM
*CURCUMIN
*ORGANOMETALLIC compounds
*COMPLEX compounds
Subjects
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 44
- Issue :
- 47
- Database :
- Academic Search Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 111182844
- Full Text :
- https://doi.org/10.1039/c5dt03037d