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Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C-N Coupling with Chiral Bisphosphine Mono-oxides.

Authors :
Hongming Li
Belyk, Kevin M.
Jingjun Yin
Qinghao Chen
Alan Hyde
Yining Ji
Oliver, Steven
Tudge, Matthew T.
Campeau, Louis-Charles
Campos, Kevin R.
Source :
Journal of the American Chemical Society. 11/4/2015, Vol. 137 Issue 43, p13728-13731. 4p.
Publication Year :
2015

Abstract

A novel approach to hemiaminal synthesis via palladium-catalyzed C-N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00027863
Volume :
137
Issue :
43
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
111151453
Full Text :
https://doi.org/10.1021/jacs.5b05934