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Epileptogenic activity induced by histamine H1 antagonists in amygdala-kindled rats
- Source :
-
Brain Research . Nov2003, Vol. 991 Issue 1/2, p258. 4p. - Publication Year :
- 2003
-
Abstract
- The epileptogenic activities induced by histamine H1 antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H1 antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats. [Copyright &y& Elsevier]
- Subjects :
- *HISTAMINE
*AMYGDALOID body
*INTRAPERITONEAL injections
Subjects
Details
- Language :
- English
- ISSN :
- 00068993
- Volume :
- 991
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 11113978
- Full Text :
- https://doi.org/10.1016/j.brainres.2003.08.009