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Exercise Training Inhibits the Nogo-A/NgR1/Rho-A Signals in the Cortical Peri-infarct Area in Hypertensive Stroke Rats.
- Source :
-
American Journal of Physical Medicine & Rehabilitation . Dec2015, Vol. 94 Issue 12, p1083-1094. 12p. - Publication Year :
- 2015
-
Abstract
- Objective: The aim of this study was to test the hypothesis that exercise training promotes motor recovery after stroke by facilitating axonal remodeling via inhibition of the Nogo-A/NgR1 and Rho-A pathway. Design: A distal middle cerebral artery occlusion model was generated in stroke-prone renovascular hypertensive rats. Stroke-prone renovascular hypertensive rats were randomly divided into a control group, an exercise training group, and a sham group. Motor function was measured using the grip strength test. Axon and myelin remodeling markers, growth-associated protein 43, myelin basic protein, Tau, and amyloid precursor protein were detected by immunofluorescence. The expression of Nogo-A, NgR1, and Rho-A was demonstrated by immunofluorescence and Western blotting in the peri-infarction area at 7, 14, 28, and 52 days after distal middle cerebral artery occlusion. Results: Grip strength was higher in the exercise training group (P< 0.05). Exercise training increased the expression of growth-associated protein 43, myelin basic protein (at 7, 14, and 28 days), and Tau (at 7 and 14 days), and decreased the expression of axonal damage amyloid precursor protein (at 7 and 14 days), compared with the control group. The protein levels of Nogo-A (at 7 and 14 days), NgR1 (at 7, 14, and 28 days), and Rho-A (at 14 and 28 days) were reduced after exercise training. Conclusions: Exercise training promotes axonal recovery, which is associated with functional improvement after cerebral infarction. Down-regulation of the Nogo-A/ NgR1 /Rho-A may mediate the axonal remodeling induced by exercise training. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANIMAL experimentation
*BIOLOGICAL models
*CELL receptors
*CEREBRAL ischemia
*CONVALESCENCE
*EXERCISE therapy
*GRIP strength
*IMMUNOHISTOCHEMISTRY
*NERVE tissue proteins
*PROBABILITY theory
*RATS
*RESEARCH funding
*STATISTICAL hypothesis testing
*STATISTICS
*STROKE
*T-test (Statistics)
*DATA analysis
*DATA analysis software
*STROKE rehabilitation
*SIGNAL peptides
Subjects
Details
- Language :
- English
- ISSN :
- 08949115
- Volume :
- 94
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- American Journal of Physical Medicine & Rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 111059081
- Full Text :
- https://doi.org/10.1097/PHM.0000000000000339