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Putting the brakes on the "drive to eat": Pilot effects of naltrexone and reward-based eating on food cravings among obese women.
- Source :
-
Eating Behaviors . Dec2015, Vol. 19, p53-56. 4p. - Publication Year :
- 2015
-
Abstract
- <bold>Purpose: </bold>Obese individuals vary in their experience of food cravings and tendency to engage in reward-driven eating, both of which can be modulated by the neural reward system rather than physiological hunger. We examined two predictions in a sample of obese women: (1) whether opioidergic blockade reduced food-craving intensity, and (2) whether opioidergic blockade reduced an association between food-craving intensity and reward-driven eating, which is a trait-like index of three factors (lack of control over eating, lack of satiation, preoccupation with food).<bold>Methods: </bold>Forty-four obese, pre-menopausal women completed the Reward-Based Eating Drive (RED) scale at study start and daily food-craving intensity on 5 days on which they ingested either a pill-placebo (2 days), a 25 mg naltrexone dose (1 day), or a standard 50mg naltrexone dose (2 days).<bold>Results: </bold>Craving intensity was similar under naltrexone and placebo doses. The association between food-craving intensity and reward-driven eating significantly differed between placebo and 50mg naltrexone doses. Reward-driven eating and craving intensity were significantly positively associated under both placebo doses. As predicted, opioidergic blockade (for both doses 25mg and 50mg naltrexone) reduced the positive association between reward-driven eating and craving intensity to non-significance.<bold>Conclusions: </bold>Opioidergic blockade did not reduce craving intensity; however, blockade reduced an association between trait-like reward-driven eating and daily food-craving intensity, and may help identify an important endophenotype within obesity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NALTREXONE
*OBESITY & psychology
*NARCOTIC antagonists
*CLINICAL trials
*COMPARATIVE studies
*DESIRE
*INGESTION
*RESEARCH methodology
*MEDICAL cooperation
*OBESITY
*RESEARCH
*RESEARCH funding
*REWARD (Psychology)
*PILOT projects
*EVALUATION research
*TREATMENT effectiveness
*THERAPEUTICS
*PSYCHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 14710153
- Volume :
- 19
- Database :
- Academic Search Index
- Journal :
- Eating Behaviors
- Publication Type :
- Academic Journal
- Accession number :
- 110855289
- Full Text :
- https://doi.org/10.1016/j.eatbeh.2015.06.008