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Identification of the Polyketide Biosynthetic Machineryfor the Indolizidine Alkaloid Cyclizidine.
- Source :
-
Organic Letters . Nov2015, Vol. 17 Issue 21, p5344-5347. 4p. - Publication Year :
- 2015
-
Abstract
- The cyclizidine biosynthetic genecluster was identified from StreptomycesNCIB 11649,which revealed the polyketide biosyntheticmachinery for cyclizidine alkaloid biosynthesis. Both in vivomutagenesis study and in vitrobiochemical analysisprovided insight into the timing and mechanism of the biosyntheticenzymes that produce cyclizidine-type indolizidine alkaloids. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 17
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 110803423
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b02707