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E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.
- Source :
-
Developmental Cell . Nov2015, Vol. 35 Issue 3, p269-280. 12p. - Publication Year :
- 2015
-
Abstract
- The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners—the Inhibitor of DNA-binding (ID) proteins—also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15345807
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Developmental Cell
- Publication Type :
- Academic Journal
- Accession number :
- 110741748
- Full Text :
- https://doi.org/10.1016/j.devcel.2015.10.019