Význam sérových hladin CRP, Lp-PLA2, leptinu a lipokalinu-2 u pacientů s lupénkou.

Psoriasis is a systemic inflammatory disease. Genetic and environmental factors play a role in its pathogenesis. Recent studies refer to association between psoriasis with metabolic syndrome and cardiovascular disease. In our study we examined changes in serum levels of selected indicators of inflammation such as C-reactive protein (CRP), lipoprotein associated phospholipase A2 (LpPLA2), adiponectin, leptin, lipocalin 2, resistin and retinol binding protein 4 (RBP4). Serum indicators were measured and compared in 32 patients with moderate to severe psoriasis (median PASI 17,1) and in 24 healthy controls (donors of blood). Significantly higher levels of CRP, LpPLA2, lipocalin 2 and leptin were found in patients with psoriasis compared to the control group. Negative correlation were observed between body mass index BMI and adiponectin, positive correlations were found between BMI and leptin and between BMI and lipocalin 2 in patients with psoriasis. Indicators like CRP, LpPLA2, lipocalin 2 and leptin could be used to asses the systemic involvement in psoriasis and to recognition and treatment of psoriatic comorbidities early. [ABSTRACT FROM AUTHOR]