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Generation of cancer-specific CD8+ CD69+ cells inhibits colon cancer growth.
- Source :
-
Immunobiology . Jan2016, Vol. 221 Issue 1, p1-5. 5p. - Publication Year :
- 2016
-
Abstract
- The therapy of colon cancer (Cca) is poor currently. The abnormality of immune function is recognized in cancer-bearing hosts. This study aims to inhibit Cca growth with the in vivo induction of Cca-specific CD8 + CD69 + T cell polarization. In this study, a mouse tumor model was created with a mouse colon cancer (Cca) cell line. The Cca-bearing mice were immunized with Cca extracts and alum (using as an adjuvant). The CD8 + CD69 + cell polarization status was analyzed by flow cytometry and enzyme-linked immunosorbent assay. The results showed that a Cca antigen-specific CD8 + CD69 + cells were induced in the Cca-bearing mice. The Cca growth was efficiently inhibited by the Cca-specific CD8 + CD69 + cell response. The Cca-specific CD8 + CD69 + cells were detected in the Cca mass and spleen, which had the ability to induce Cca cell apoptosis. In conclusion, the Cca-specific CD8 + CD69 + cell polarization can be induced in Cca-bearing mice, which can efficiently inhibit the Cca growth. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01712985
- Volume :
- 221
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 110703170
- Full Text :
- https://doi.org/10.1016/j.imbio.2015.08.010