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Body mass index influence interferon-beta treatment response in multiple sclerosis.
- Source :
-
Journal of Neuroimmunology . Nov2015, Vol. 288, p92-97. 6p. - Publication Year :
- 2015
-
Abstract
- Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI ≥ 25 kg/m 2 ) had MRI activity compared to 48% of the normal-weight patients (BMI < 25 kg/m 2 ) (p = 0.001) during interferon-beta treatment. NEDA-status (no evidence of disease activity) was defined as a composite that consisted of absence of any relapses, sustained disability-progression and MRI-activity. Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI > 25 (p = 0.05). This may indicate that BMI affects interferon-beta treatment response. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 288
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 110656866
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2015.09.008