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Antimicrobial and antimycobacterial activities of aliphatic amines derived from vanillin.
- Source :
-
Canadian Journal of Chemistry . Nov2015, Vol. 93 Issue 11, p1305-1311. 7p. 5 Diagrams, 2 Charts. - Publication Year :
- 2015
-
Abstract
- Ten lipophilic amines were prepared from the reductive amination of vanillin and the corresponding primary amines using sodium borohydride in methanol. All compounds have been obtained elementally pure and an X-ray diffraction study on the 4- n-butylaniline derivative has confirmed the molecular structure. Whilst the overall antibiotic activity of the derivatives was low, some of these compounds, particularly the boronate ester 2-methoxy-4-((2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylamino)methyl)phenol ( 7), showed a promising degree of antimycobacterial activity against Mycobacterium tuberculosis H37Ra, where activity seemed to vary by the position of the boron substitution on the aniline ring. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00084042
- Volume :
- 93
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Canadian Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 110590265
- Full Text :
- https://doi.org/10.1139/cjc-2015-0400