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BMI levels with MS Bone mineral density levels in adults with multiple sclerosis: a meta-analysis.

Authors :
Huang, Zhongming
Qi, Yiying
Du, Shaohua
Chen, Guangnan
Yan, Weiqi
Source :
International Journal of Neuroscience. Dec2015, Vol. 125 Issue 12, p904-912. 9p.
Publication Year :
2015

Abstract

Introduction: Multiple sclerosis (MS) and osteoporosis (OP) affect a substantial proportion of the population. Accumulating evidence suggests that MS patients are at high risk for OP. We performed a meta-analysis to identify risk factors for lowered bone mineral density (BMD) in MS patients.Methods: We searched for articles within the Medline, Embase and Cochrane Library databases, published up to March 2014, pertaining to associations between MS and BMD. A total of 11 studies was included in the meta-analysis.Results: The analysis indicated that MS patients have reduced lumbar spine, femur neck, and hip BMD compared with healthy controls (lumbar spine, standardized mean difference (SMD) = −0.76, 95% CI: −1.07, −0.45; femur neck, SMD = −0.56, 95% CI: −0.84, −0.29; and hip, SMD = −0.62, 95% CI: −0.96, −0.29). Further subgroup analysis revealed that a disease duration of >7 years, total steroid dose during the disease of >15 g, and an Expanded Disability Status Scale (EDSS) score of > 3, increased the risk of reduced BMD in the lumbar spine and femoral neck, but not in the hip. Meta-regression analysis did not explain the heterogeneity in the clinical characteristics or outcome definitions.Conclusions: Our meta-analysis suggests that MS patients have reduced overall BMD compared with healthy controls. Furthermore, disease duration (>7 years), total steroid dose (>15 g), and EDSS score (>3) are risk factors for reduced BMD in MS patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00207454
Volume :
125
Issue :
12
Database :
Academic Search Index
Journal :
International Journal of Neuroscience
Publication Type :
Academic Journal
Accession number :
110572901
Full Text :
https://doi.org/10.3109/00207454.2014.988332