A highly sensitive SERS sensor for quantitative analysis of glucose based on the chemical etching of silver nanoparticles.

A highly sensitive and facile ‘turn-off’ surface-enhanced Raman scattering (SERS) sensor based on the etching effect on silver nanoparticles (Ag NPs) was designed for the determination of glucose. Ag NPs marked with Raman tags of 4-mercaptopyridine (4-mpy) were assembled on the glass slide by layer-by-layer self-assembly to form a SERS chip. When this SERS chip was exposed to different concentrations of glucose and glucose oxidase-mixed solutions, the produced H2O2 started to etch the Ag NPs, leading to the SERS signal of 4-mpy decreasing. Therefore, we can trace the SERS intensity of 4-mpy to determine the glucose concentration, and the lowest detectable concentration can reach 10 μM. This glucose sensor has the promising potential of detection for clinical blood in the future. [ABSTRACT FROM AUTHOR]