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Characterization of human humoral responses to the major outer membrane protein and OMP2 of Chlamydophila pneumoniae
- Source :
-
FEMS Microbiology Letters . Oct2003, Vol. 227 Issue 1, p73. 7p. - Publication Year :
- 2003
-
Abstract
- Chlamydophila pneumoniae infection is associated with a range of diseases including pneumonia, asthma and heart disease. Although an obligate intracellular pathogen, high levels of antigen-specific antibody are induced and serology is frequently used to diagnose these infections. Proteins targeted by the humoral response include the major outer membrane protein (MOMP) and outer membrane protein 2 (OMP2). Using human anti-chlamydial sera we have defined the B cell epitopes recognized on MOMP and OMP2. Peptides from MOMP, unlike OMP2, were not strongly recognized. Two of these epitopes when linked to an inert carrier reacted strongly with high-titer anti-C. pneumoniae sera. [Copyright &y& Elsevier]
- Subjects :
- *MEMBRANE proteins
*PNEUMONIA
Subjects
Details
- Language :
- English
- ISSN :
- 03781097
- Volume :
- 227
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- FEMS Microbiology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 11042970
- Full Text :
- https://doi.org/10.1016/S0378-1097(03)00650-5