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Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder.
- Source :
-
Journal of Child & Adolescent Psychopharmacology . Oct2015, Vol. 25 Issue 8, p633-640. 8p. - Publication Year :
- 2015
-
Abstract
- <bold>Objectives: </bold>The purpose of this study is to examine the relationship between 5-HTTLPR polymorphism (44-bp insertion/deletion polymorphism of serotonin transporter gene) and methylphenidate (MPH) treatment response, as well as the association between the adverse events of MPH treatment and 5-HTTLPR polymorphism in children with attention-deficit/hyperactivity disorder (ADHD).<bold>Methods: </bold>A total of 114 children with ADHD (mean age 9.08 ± 1.94 years) were recruited from the child psychiatric clinic in a hospital in South Korea. We have extracted the genomic DNA of the subjects from their blood lymphocytes and analyzed 5-HTTLPR polymorphism of the SLC6A4 gene. All children were treated with MPH for 8 weeks, with clinicians monitoring both the improvement of ADHD symptoms and the side effects. We compared the response to MPH treatment and adverse events among those with the genotype of 5-HRRLPR polymorphism.<bold>Results: </bold>There was no significant association between the 5-HTTLPR genotype and the response to MPH treatment in children with ADHD. Subjects with the S/L+L/L genotype tended to have tics and nail biting (respectively, p < 0.001, p = 0.017).<bold>Conclusions: </bold>The results of this study do not support the association between the 5-HTTLPR polymorphism and treatment response with MPH in ADHD. However, our findings suggest the association between 5-HTTLPR polymorphism and the occurrence of tics and nail-biting as an adverse event of methylphenidate. This may aid in our understanding of the genetic contribution and genetic susceptibility of a particular allele in those ADHD patients with tics or nail biting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TREATMENT of attention-deficit hyperactivity disorder
*SEROTONIN transporters
*METHYLPHENIDATE
*TIC disorders
*GENETIC polymorphisms
*KOREANS
*DISEASES
*ALLELES
*ATTENTION-deficit hyperactivity disorder
*COMPARATIVE studies
*HABIT
*RESEARCH methodology
*MEDICAL cooperation
*MEMBRANE proteins
*RESEARCH
*EVALUATION research
*TREATMENT effectiveness
*CENTRAL nervous system stimulants
*GENOTYPES
*DISEASE complications
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10445463
- Volume :
- 25
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Child & Adolescent Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 110427990
- Full Text :
- https://doi.org/10.1089/cap.2014.0168