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Effectiveness of Prenatal Screening for Hemoglobinopathies in a Developing Country.
- Source :
-
Hemoglobin . Dec2015, Vol. 39 Issue 6, p380-383. 4p. - Publication Year :
- 2015
-
Abstract
- The thalassemias are among the most common monogenic diseases worldwide, a national health burden in India. There are estimated 7500–12,000 babies born with β-thalassemia major (β-TM) every year in this country. Couples who are at-risk of having children with hemoglobin (Hb) disorders desired to have the option of avoiding the birth of an affected child by prenatal diagnosis (PND). Thus, the prenatal women are a highly important target group for carrier screening and preventing the birth of thalassemic children in the country. The present study was conducted among 20,883 pregnant women, irrespective of gravida and duration of pregnancy, from the prenatal clinic of Nilratan Sarkar (NRS) Medical College & Hospital, Kolkata, West Bengal, India, from February 2009 to November 2012. Thalassemia carrier status was assessed by high performance liquid chromatography (HPLC) along with red blood cell (RBC) indices. Husbands of all thalassemia carrier women were advised and persuaded to undergo screening for hemoglobinopathies. The couples were counseled to undergo PND if both of them were detected to be thalassemia carriers. The data were statistically analyzed to evaluate the efficacy of this procedure. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03630269
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Hemoglobin
- Publication Type :
- Academic Journal
- Accession number :
- 110427135
- Full Text :
- https://doi.org/10.3109/03630269.2014.1003564