Back to Search
Start Over
Effect of Intracoronary Plus Low-Dose Intravenous Tirofiban in Elderly Patients with Acute Myocardial Infarction.
- Source :
-
Heart, Lung & Circulation . Nov2015, Vol. 24 Issue 11, p1062-1067. 6p. - Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>To investigate the efficacy and safety of low-dose tirofiban in elderly patients undergoing primary percutaneous coronary intervention (PPCI) for acute myocardial infarction (AMI).<bold>Methods: </bold>One hundred and four patients aged 70 years and above undergoing PPCI for AMI were divided into control (n=52) and study (n=52) groups. All patients received bolus intracoronary injection of tirofiban (10μg/kg), which was followed by intravenous infusion at 0.15μg/kg/min in the control group and at 0.075μg/kg/min in the study group for 24h.<bold>Results: </bold>There was no statistically significant difference between the study group and the control group in patients with complete ST segment resolution (84.2% vs. 85.7%, P=0.851), peak high-sensitive cardiac troponin T level (5.1±1.9 vs. 5.8±2.6μg/L, P=0.123), scores of thrombus in the infarct-related artery (0.98±0.51 vs. 1.12±0.59, P=0.214), and patients with TIMI grade 3 flow (86.0% vs. 88.2%, P=0.737) after PPCI. There were no statistically significant differences between the two groups in left ventricular ejection fraction (57.1±6.3 vs. 57.7±6.1, P=0.611) and composite major adverse cardiovascular events rate (P =0.778) at 90 days after PCI. The total bleeding rate in the study group was lower than in the control group (P=0.048).<bold>Conclusion: </bold>In elderly patients with AMI undergoing primary PCI, low and standard dose of tirofiban exerts similar effects on platelet aggregation, coronary flow, infarct size, left ventricular systolic function and short-term clinical outcomes. Low dose regimen is associated with a lower bleeding rate than the standard dose. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TIROFIBAN
*MYOCARDIAL infarction treatment
*MYOCARDIAL infarction
*PERCUTANEOUS coronary intervention
*VENTRICULAR ejection fraction
*PATIENTS
*THERAPEUTICS
*CARDIOVASCULAR system
*CLINICAL trials
*COMPARATIVE studies
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL care
*MEDICAL cooperation
*RESEARCH
*TYROSINE
*EVALUATION research
*TROPONIN
*STROKE volume (Cardiac output)
Subjects
Details
- Language :
- English
- ISSN :
- 14439506
- Volume :
- 24
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Heart, Lung & Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 110409006
- Full Text :
- https://doi.org/10.1016/j.hlc.2015.04.161