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Dust metal loadings and the risk of childhood acute lymphoblastic leukemia.
- Source :
-
Journal of Exposure Science & Environmental Epidemiology . Nov/Dec2015, Vol. 25 Issue 6, p593-598. 6p. 4 Charts. - Publication Year :
- 2015
-
Abstract
- We evaluated the relationship between the risk of childhood acute lymphoblastic leukemia (ALL) and the levels of metals in carpet dust. A dust sample was collected from the homes of 142 ALL cases and 187 controls participating in the California Childhood Leukemia Study using a high volume small surface sampler (2001-2006). Samples were analyzed using microwave-assisted acid digestion in combination with inductively coupled plasma mass spectrometry for arsenic, cadmium, chromium, copper, lead, nickel, tin, tungsten, and zinc. Eight metals were detected in at least 85% of the case and control homes; tungsten was detected in <15% of homes. Relationships between dust metal loadings (μg metal per m2 carpet) and ALL risk were modeled using multivariable logistic regression, adjusting for the child's age, sex, and race/ethnicity and confounders, including household annual income. A doubling of dust metal loadings was not associated with significant changes in ALL risk (odds ratio (95% confidence interval): arsenic: 0.96 (0.86, 1.07), cadmium: 0.92 (0.81, 1.05), chromium: 1.01 (0.90, 1.14), copper: 0.97 (0.91, 1.03), lead: 1.01 (0.93, 1.10), nickel: 0.95 (0.82, 1.09), tin: 0.96 (0.86, 1.08), and zinc: 0.94 (0.84, 1.05)). Our findings do not support the hypothesis that metals in carpet dust are risk factors for childhood ALL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15590631
- Volume :
- 25
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Exposure Science & Environmental Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 110398587
- Full Text :
- https://doi.org/10.1038/jes.2015.9