Highly Enantioselective Intramolecular Morita-Baylis-Hillman Reaction Catalyzed by Mannose-Based Thiourea-phosphine.

The saccharide-based chiral bifunctional thiourea-phosphines were developed as chiral organocatalysts for the intramolecular Morita-Baylis-Hillman reaction of ω-formyl-enones. With only 2 mol% of thiourea-phosphine catalyst 3c, chiral functionalized cyclohexenes were achieved under mild reaction conditions with excellent yields and enantioselectivities. [ABSTRACT FROM AUTHOR]