Back to Search
Start Over
Long-Term Impact of Endometrial Cancer Diagnosis and Treatment on Health-Related Quality of Life and Cancer Survivorship: Results From the Randomized PORTEC-2 Trial.
- Source :
-
International Journal of Radiation Oncology, Biology, Physics . Nov2015, Vol. 93 Issue 4, p797-809. 13p. - Publication Year :
- 2015
-
Abstract
- <bold>Purpose: </bold>To evaluate the long-term health-related quality of life (HRQL) after external beam radiation therapy (EBRT) or vaginal brachytherapy (VBT) among PORTEC-2 trial patients, evaluate long-term bowel and bladder symptoms, and assess the impact of cancer on these endometrial cancer (EC) survivors. <bold>Patients and Methods: </bold>In the PORTEC-2 trial, 427 patients with stage I high-intermediate-risk EC were randomly allocated to EBRT or VBT. The 7- and 10-year HRQL questionnaires consisted of EORTC QLQ-C30; subscales for bowel and bladder symptoms; the Impact of Cancer Questionnaire; and 14 questions on comorbidities, walking aids, and incontinence pads. Analysis was done using linear mixed models for subscales and (ordinal) logistic regression with random effects for single items. A two-sided P value <.01 was considered statistically significant. <bold>Results: </bold>Longitudinal HRQL analysis showed persisting higher rates of bowel symptoms with EBRT, without significant differences in global health or any of the functioning scales. At 7 years, clinically relevant fecal leakage was reported by 10.6% in the EBRT group, versus 1.8% for VBT (P=.03), diarrhea by 8.4% versus 0.9% (P=.04), limitations due to bowel symptoms by 10.5% versus 1.8% (P=.001), and bowel urgency by 23.3% versus 6.6% (P<.001). Urinary urgency was reported by 39.3% of EBRT patients, 25.5% for VBT, P=.05. No difference in sexual activity was seen between treatment arms. Long-term impact of cancer scores was higher among the patients who had an EC recurrence or second cancer. <bold>Conclusions: </bold>More than 7 years after treatment, EBRT patients reported more bowel symptoms with impact on daily activities, and a trend for more urinary symptoms, without impact on overall quality of life or difference in cancer survivorship issues. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMPARATIVE studies
*DIARRHEA
*FECAL incontinence
*HEALTH status indicators
*RESEARCH methodology
*MEDICAL cooperation
*MEDICAL supplies
*QUALITY of life
*QUESTIONNAIRES
*RADIOISOTOPE brachytherapy
*RADIOTHERAPY
*REGRESSION analysis
*RESEARCH
*HUMAN sexuality
*TIME
*TUMOR classification
*URINARY incontinence
*ACTIVITIES of daily living
*ENDOMETRIAL tumors
*EVALUATION research
*RANDOMIZED controlled trials
*URINARY urge incontinence
*PSYCHOLOGY
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 03603016
- Volume :
- 93
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Radiation Oncology, Biology, Physics
- Publication Type :
- Academic Journal
- Accession number :
- 110347233
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2015.08.023