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Sibjotang Increases Atrial Natriuretic Peptide Secretion in Beating Rabbit Atria.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 10/1/2015, Vol. 2015, p1-11. 11p. 1 Diagram, 6 Graphs. - Publication Year :
- 2015
-
Abstract
- Sibjotang (Shizaotang), traditional herbal medicine formula, which was first documented in the Shanghanlun, has long been prescribed for the treatment of impairment of the body fluid homeostasis. The purpose of the present study was to identify the effects of Sibjotang on the secretion of a cardiac hormone, atrial natriuretic peptide (ANP), one of the main hormones involved in the regulation of the body fluid and blood pressure homeostasis. Water extract of Sibjotang increased ANP secretion concomitantly with an increase in atrial dynamics in a concentration-dependent manner. Sibjotang-induced increase in ANP secretion and positive inotropic effect were attenuated by GO6976 and LY333531, selective inhibitors of conventional protein kinase C, but not Rottlerin, an inhibitor of novel PKCĪ“. Similarly to the effect of Sibjotang, extracts of components of Sibjotang, Euphorbia kansui, and Daphne genkwa, but not Euphorbia pekinensis and Ziziphus jujuba, increased ANP secretion and atrial dynamics. Ingredients of Sibjotang, apigenin, rosmarinic acid, and salvianolic acid B decreased ANP secretion and atrial dynamics. These findings suggest that Sibjotang increases ANP secretion and atrial dynamics via activation of conventional protein kinase C signaling. This finding provides experimental evidence for the rationale in the use of Sibjotang in the treatment of impairment of the regulation of body fluid and blood pressure homeostasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANIMAL experimentation
*ATRIAL natriuretic peptides
*BLOOD pressure
*BODY fluids
*HEART atrium
*HIGH performance liquid chromatography
*HOMEOSTASIS
*LACTATE dehydrogenase
*MEDICINAL plants
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*PROTEIN kinases
*RABBITS
*RADIOIMMUNOASSAY
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*PHYTOCHEMICALS
*PLANT extracts
*DATA analysis
*ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2015
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 110311789
- Full Text :
- https://doi.org/10.1155/2015/268643