Impact of low-frequency ultrasound on endometrial receptors: possibilities of rehabilitation after non-developing pregnancy.

For evaluating the effectiveness of intrauterine ultrasonic cavitational irrigation to restore the endometrium in women after pregnancy regression in the first trimester, 70 patients were randomly divided into two groups: group 1 – 38 patients, who received in combination therapy the intrauterine ultrasonic cavitation irrigation, and group 2 – 32 patients, in which treatment is not carried out by intrauterine irrigation. Intrauterine cavitation irrigation was carried out on the third day after regressing pregnancy interruption by unit “Fotek АК100” (five treatments for 3–5 min each). Immunohistochemical study of the endometrium, taken by pipelle-biopsy, was carried out at 7–10 d of the next menstrual cycle. ERα expression in endometrial glands in the group 1 was 188.54 ± 1.97, and group 2 was 177.01 ± 5.29 (p < 0.05). Stromal ERα demonstrated no significant differences in observation group, but they were below the reference values. Stromal PR expression in group 1 was 159.09 ± 4.82, whereas group 2 showed 143.01 ± 8.19 (p < 0.05); in the glands 196.18 ± 1.94 in the group 1, 181.66 ± 3.18 in the group 2 (p < 0.01). Ki67 expression in the glands was 145.63 ± 5.43 in group 1, 168.33 ± 14.59 in group 2; the control values 132.51 ± 4.25 (p < 0.01). Intrauterine ultrasonic cavitational irrigation after pregnancy regression is an effective rehabilitation technology of endometrial receptive area. [ABSTRACT FROM PUBLISHER]