Highly practical oxidation of benzylic alcohol in continuous-flow system with metal-free catalyst.

Authors :: Liu, Chengkou
Fang, Zheng
Yang, Zhao
Li, Qingwen
Guo, Shiyu
Zhang, Kai
Ouyang, Pingkai
Guo, Kai
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Oct2015, Vol. 56 Issue 44, p5973-5976. 4p.
Publication Year :: 2015
Abstract: Oxidation of benzylic alcohol to ketone or aldehyde is one of the most challenging reactions in terms of green chemistry. We report herein that employing H 2 O 2 , catalytic amount of Br − and acid in continuous-flow system to realize oxidation of benzylic alcohols with broad substrate scope and high selectivity. More importantly, no over oxidation to acid was obtained and it showed higher selectivity to 2° hydroxyl groups rather than 1°. [ABSTRACT FROM AUTHOR]

Subjects :: *BENZYLIC group
*ALCOHOL oxidation
*CONTINUOUS flow reactors
*METAL catalysts
*ALDEHYDES
*KETONES
*SUSTAINABLE chemistry

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 44
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 110185854
Full Text :: https://doi.org/10.1016/j.tetlet.2015.07.069

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