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Pterocarpans and triterpenoids from Gueldenstaedtia verna.
- Source :
-
Fitoterapia . Oct2015, Vol. 106, p46-54. 9p. - Publication Year :
- 2015
-
Abstract
- Two new pterocarpan glycosides ( 1 – 2 ), five new triterpenoids ( 3 – 7 ), and 13 known analogues ( 14 – 20 ) were isolated from the whole plants of Gueldenstaedtia verna . These new compounds ( 1 – 7 ) were elucidated by extensive spectroscopic techniques including 1D ( 1 H and 13 C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALTERNATIVE medicine
*ANIMAL experimentation
*ANTI-inflammatory agents
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*PHYSICAL & theoretical chemistry
*MASS spectrometry
*MEDICINAL plants
*MICE
*NITRIC oxide
*NUCLEAR magnetic resonance spectroscopy
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 106
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 110149372
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.07.021