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Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis.
- Source :
-
Trends in Analytical Chemistry: TRAC . Oct2015, Vol. 72, p68-79. 12p. - Publication Year :
- 2015
-
Abstract
- This year marks the 150th anniversary of the first continuous-flow chemistry (CFC) technique, developed by Ernest Solvay, which revolutionized industrial level synthesis. CFC is defined by multi-stage processes in which mixing and reacting of chemicals occur without interruption. A significant challenge of CFC lies in post-reaction purification. Free-flow electrophoresis (FFE) could be integrated with CFC. FFE separates chemicals by an electric field that is directed orthogonally to a pressure driven hydrodynamic flow. Although there are problems with FFE, both macro-scale and small-scale FFE are feasible for CFC integration, and realizing long-term steady-state continuous-flow purification can have significant benefits. In this review, we discuss (i) the progress of CFC, (ii) existing continuous-flow purification techniques, (iii) small-scale FFE limitations associated with steady-state continuous-flow purification, and (iv) advances in FFE performance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01659936
- Volume :
- 72
- Database :
- Academic Search Index
- Journal :
- Trends in Analytical Chemistry: TRAC
- Publication Type :
- Academic Journal
- Accession number :
- 110099959
- Full Text :
- https://doi.org/10.1016/j.trac.2015.03.023