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Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

Authors :
Hoh, Alexander
Heeg, Maximilian
Yi Ni
Schuch, Anita
Binder, Benedikt
Hennecke, Nadine
Blum, Hubert E.
Nassal, Michael
Protzer, Ulrike
Hofmann, Maike
Urban, Stephan
Thimme, Robert
Source :
Journal of Virology. Jul2015, Vol. 89 Issue 14, p7433-7438. 6p.
Publication Year :
2015

Abstract

CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0022538X
Volume :
89
Issue :
14
Database :
Academic Search Index
Journal :
Journal of Virology
Publication Type :
Academic Journal
Accession number :
110092067
Full Text :
https://doi.org/10.1128/JVI.00605-15