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Cohort Profile: The Barwon Infant Study.
- Source :
-
International Journal of Epidemiology . Aug2015, Vol. 44 Issue 4, p1148-1160. 13p. - Publication Year :
- 2015
-
Abstract
- The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au]. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03005771
- Volume :
- 44
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 110078727
- Full Text :
- https://doi.org/10.1093/ije/dyv026