Dinardokanshones A and B, two unique sesquiterpene dimers from the roots and rhizomes of Nardostachys chinensis.

Authors :: Wu, Hong-Hua
Chen, Ying-Peng
Ying, Shu-Song
Zhang, Peng
Xu, Yan-Tong
Gao, Xiu-Mei
Zhu, Yan
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Oct2015, Vol. 56 Issue 43, p5851-5854. 4p.
Publication Year :: 2015
Abstract: Dinardokanshones A ( 1 ) and B ( 2 ), two unique sesquiterpene dimers were isolated from the roots and rhizomes of Nardostachys chinensis Batal. (Valerianaceae). Their structures were revealed by extensive spectroscopic analysis, and the absolute configurations were established by reported rules and computational electronic circular dichroism (ECD) method. Dinardokanshone B characteristically contains an aristolane lactone with an unusual 3/5/5/6 tetracyclic ring system. Based on a high-content assay for testing serotonin transporter (SERT) function, the two compounds showed significant enhancement effects on SERT activity. [ABSTRACT FROM AUTHOR]

Subjects :: *SESQUITERPENES
*PLANT roots
*CIRCULAR dichroism
*LACTONES
*SEROTONIN transporters

Language :: English
ISSN :: 00404039
Volume :: 56
Issue :: 43
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 109980125
Full Text :: https://doi.org/10.1016/j.tetlet.2015.08.079

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