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Facile Baeyer–Villiger oxidation of cyclic ketones: conventional versus microwave-assisted approach.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Oct2015, Vol. 56 Issue 42, p5723-5726. 4p. - Publication Year :
- 2015
-
Abstract
- The Baeyer–Villiger oxidation of cyclic ketones (I) to the corresponding lactones (II) can be improved using m -CPBA under microwave dielectric heating. A dramatic reduction of time—3 min compared to 5 days at room temperature—was observed to transform cycloheptanone into oxocan-2-one. Ω-Hydroxyalkyl hydroxamic acids (III), key intermediates for a rapid access to potent histone deacetylase inhibitors, are obtained in one-pot reaction of lactones using the Weinreb amidation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 56
- Issue :
- 42
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 109551267
- Full Text :
- https://doi.org/10.1016/j.tetlet.2015.08.082