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Disfuncionalidad antioxidante de las lipoproteínas de alta densidad (HDL) en pacientes diabéticos descompensados.
- Source :
-
Nutrición Hospitalaria . sep2015, Vol. 32 Issue 3, p1131-1138. 8p. - Publication Year :
- 2015
-
Abstract
- Introduction: high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. Aim: to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. Methods: the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. Results: the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. Conclusion: HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Spanish
- ISSN :
- 02121611
- Volume :
- 32
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nutrición Hospitalaria
- Publication Type :
- Academic Journal
- Accession number :
- 109515474
- Full Text :
- https://doi.org/10.3305/nh.2015.32.3.9340