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Unexpectedly long half-lives of blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) levels in Yusho patients.
- Source :
-
Environmental Health: A Global Access Science Source . 9/18/2015, Vol. 14 Issue 1, p1-6. 6p. 1 Chart, 3 Graphs. - Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>Dioxins and dioxin-like compounds have half-lives typically between 7.2 years and 15 years. Our previous study of patients poisoned by extremely high concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in the 'Yusho incident' in 1968 found that in some the half-life of blood 2,3,4,7,8-PeCDF tended towards infinity. This suggests that there are two groups of Yusho patients, those with 2,3,4,7,8-PeCDF half-lives around 10 years, and those with half-lives near infinity. We sought to establish the proportions of each in a cohort of 395 Yusho patients, and whether the proportions were changing over time.<bold>Methods: </bold>We undertook longitudinal measurement of the blood concentration of 2,3,4,7,8-PeCDF in our cohort between 2002 and 2010. We estimated the change in concentration for each patient using linear regression for measured 2,3,4,7,8-PeCDF concentration, then compared the distribution of changes in concentrations with our previous study.<bold>Results: </bold>In patients in whom the blood concentration of 2,3,4,7,8-PeCDF exceeded 50 pg/g lipid, the proportion 8.0% of patients exhibiting half-lives less than 13.3 years fell compared with our previous study (28.2%), while the proportion with near infinity half-lives increased.<bold>Conclusion: </bold>The prolongation of the half-lives was likely a consequence of age-related factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOOD contamination
*HETEROCYCLIC compounds
*POLLUTANTS
*TIME
Subjects
Details
- Language :
- English
- ISSN :
- 1476069X
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Environmental Health: A Global Access Science Source
- Publication Type :
- Academic Journal
- Accession number :
- 109511937
- Full Text :
- https://doi.org/10.1186/s12940-015-0059-y