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Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism.

Authors :
Huasong Lu
Yuhua Xue
Guoying K. Yu
Arias, Carolina
Lin, Julie
Fong, Susan
Faure, Michel
Weisburd, Ben
Xiaodan Ji
Mercier, Alexandre
Sutton, James
Kunxin Luo
Zhenhai Gao
Qiang Zhou
Source :
eLife. Jun2015, p1-26. 26p.
Publication Year :
2015

Abstract

The article presents a study that determines the potential of cyclin-dependent kinase 9 (CDK9) and MYC/BRD4 in inducing growth arrest and apoptosis of cancer cells.

Details

Language :
English
ISSN :
2050084X
Database :
Academic Search Index
Journal :
eLife
Publication Type :
Academic Journal
Accession number :
109353083
Full Text :
https://doi.org/10.7554/eLife.06535