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Repeated intranasal exposure to microcystin-LR affects lungs but not nasal epithelium in mice.
- Source :
-
Toxicon . Sep2015, Vol. 104, p14-18. 5p. - Publication Year :
- 2015
-
Abstract
- Microcystin-LR (MC-LR) is a harmful cyanotoxin able to induce adverse outcomes in the respiratory system. We aimed to examine the lungs and nasal epithelium of mice following a sub-chronic exposure to MC-LR. Swiss mice were intranasally instilled with 10 μL of distilled water (CTRL, n = 10) or 6.7 ng/kg of MC-LR diluted in 10 μL of distilled water (TOX, n = 8) during 30 consecutive days. Respiratory mechanics was measured in vivo and histology measurements (morphology and inflammation) were assessed in lungs and nasal epithelium samples 24 h after the last intranasal instillation. Despite the lack of changes in the nasal epithelium, TOX mice displayed an increased amount of PMN cells in the lungs (× 10 −3 /μm 2 ), higher lung static elastance (cmH 2 O/mL), resistive and viscoelastic/inhomogeneous pressures (cmH 2 O) (7.87 ± 3.78, 33.96 ± 2.64, 1.03 ± 0.12, 1.01 ± 0.08, respectively) than CTRL (5.37 ± 4.02, 26.65 ± 1.24, 0.78 ± 0.06, 0.72 ± 0.05, respectively). Overall, our findings suggest that the nasal epithelium appears more resistant than lungs in this model of MC-LR intoxication. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00410101
- Volume :
- 104
- Database :
- Academic Search Index
- Journal :
- Toxicon
- Publication Type :
- Academic Journal
- Accession number :
- 109317003
- Full Text :
- https://doi.org/10.1016/j.toxicon.2015.07.331