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Pre-clinical formulation screening, development and stability of acetyl aspartic acid for cosmetic application.
- Source :
-
International Journal of Cosmetic Science . 2015 Supplement, Vol. 37, p28-33. 6p. - Publication Year :
- 2015
-
Abstract
- Synopsis Background Acetyl aspartic acid (A-A-A) was discovered through gene array analysis with corresponding connectivity mapping (Cmap). Using an in silico and in vitro approach, A-A-A was found increased keratinocyte regeneration, inhibited dermal expression of MMP making this compound a potential active ingredient for cosmetic application. Objectives To determine the conditions to successfully formulate A-A-A for skin delivery investigation and in vivo clinical assessment by the systematic approach of pre-formulation testing of the active, screening of formulation type on active delivery and stability evaluations. Methods Analytical evaluation of A-A-A was undertaken using LC-MS ESI method. Formulation stability was evaluated using Brookfield viscometer, pH analysis, optical microscopy and organoleptic evaluations. Results Analytical evaluation of A-A-A shows that pH significantly impacts chemical stability of the molecule. A-A-A containing formulae show minimal differences to vehicle product throughout the testing. Conclusion A-A-A is an active that can be successfully formulated in a cosmetic o/w emulsion within defined pH considerations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01425463
- Volume :
- 37
- Database :
- Academic Search Index
- Journal :
- International Journal of Cosmetic Science
- Publication Type :
- Academic Journal
- Accession number :
- 109307482
- Full Text :
- https://doi.org/10.1111/ics.12256