Back to Search
Start Over
Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients.
- Source :
-
BioMed Research International . 2/19/2015, Vol. 2015, p1-8. 8p. - Publication Year :
- 2015
-
Abstract
- Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRAIN
*RADIOGRAPHY
*CEREBRAL hemispheres
*ANXIETY testing
*AUDITORY cortex
*BRAIN mapping
*CEREBRAL cortex
*CHI-squared test
*STATISTICAL correlation
*MENTAL depression
*MAGNETIC resonance imaging
*PROBABILITY theory
*RESEARCH funding
*SELF-report inventories
*T-test (Statistics)
*TINNITUS
*DATA analysis software
*GRAY matter (Nerve tissue)
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2015
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 109273408
- Full Text :
- https://doi.org/10.1155/2015/345647