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D-Amino acids and D-Tyr-tRNATyr deacylase: stereospecificity of the translation machine revisited
- Source :
-
FEBS Letters . Sep2003, Vol. 552 Issue 2/3, p95. 4p. - Publication Year :
- 2003
-
Abstract
- Until 30 years ago, it had been considered that D-amino acids were excluded from living systems except for D-amino acids in the cell wall of microorganisms. However, D-amino acids, in the form of free amino acids, peptides and proteins, were recently detected in various living organisms from bacteria to mammals. The extensive distribution of bio-functional D-amino acids challenges the current concept of protein synthesis: more attention should be paid to the stereospecificity of the translation machine. Besides aminoacyl-tRNA synthetases, elongation factor Tu and some other mechanisms, D-Tyr-tRNATyr deacylases provide a novel checkpoint since they specifically recycle misaminoacylated D-Tyr-tRNATyr and some other D-aminoacyl-tRNAs. Their unique structure represents a new class of tRNA-dependent hydrolase. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origin. [Copyright &y& Elsevier]
- Subjects :
- *PROTEINS
*BIOSYNTHESIS
*AMINO acids
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 552
- Issue :
- 2/3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 10926220
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00858-5