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Design and Synthesis of Acyclic Nucleoside Analogs with Chlorinated Imidazo[1,2-a]pyridine Bases.
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . Oct2003, Vol. 22 Issue 10, p1907-1917. 11p. - Publication Year :
- 2003
-
Abstract
- A series of acyclic C-nucleoside analogs of 2,6-dichloro- and 2,6,7-trichloroimidazo[1,2-a]pyridine were synthesized and tested for antiviral activity. The appropriate hydroxymethyl-substituted heterocycles were treated successively with thionyl chloride, an appropriate nucleophile, then diisopropylethylamine to obtain the desired acyclic nucleoside analogs. These compounds were evaluated for activity against human cytomegalovirus and herpes simplex virus, type 1. Two of the dichloro analogs, but none of the trichloro analogs demonstrated slight antiviral activity (IC50'sā=ā20ā45āµM) at non-cytotoxic concentrations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACYCLIC model
*NUCLEOSIDES
*IMIDAZOLES
*PYRIDINE
*ANTIVIRAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 22
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 10921400
- Full Text :
- https://doi.org/10.1081/NCN-120025238