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Genotoxic Activities of Drug-Nitrite Interaction Products.

Authors :
Özhan, Gül
Alpertunga, Buket
Source :
Drug & Chemical Toxicology. 2003, Vol. 26 Issue 4, p295-308. 14p.
Publication Year :
2003

Abstract

At first 28 orally administered drugs, considered to be potentially nitrosatable on the basis of their chemical structure, have been nitrosated with nitrite under simulated stomach conditions. A maximum daily dose of each drug was incubated with a nitrite concentration that can be found after a normal meal in the stomach at 37°C over 1 h. Reaction was started at pH 6.8–7.0 and stopped at pH 2.0, so we had the same pH change that occurs in the stomach. Secondly the genotoxic activities of drug-nitrite interaction products were tested by the umu-test with Salmonella typhimurium TA 1535/pSK1002 as tester strain in the presence and absence of metabolic activation. By the umu-test, among the nitrosation products of drugs examined 22 products showed genotoxicity at different levels. Other six products showed negative results by the umu-test. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01480545
Volume :
26
Issue :
4
Database :
Academic Search Index
Journal :
Drug & Chemical Toxicology
Publication Type :
Academic Journal
Accession number :
10921342
Full Text :
https://doi.org/10.1081/DCT-120024844