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Genotoxic Activities of Drug-Nitrite Interaction Products.
- Source :
-
Drug & Chemical Toxicology . 2003, Vol. 26 Issue 4, p295-308. 14p. - Publication Year :
- 2003
-
Abstract
- At first 28 orally administered drugs, considered to be potentially nitrosatable on the basis of their chemical structure, have been nitrosated with nitrite under simulated stomach conditions. A maximum daily dose of each drug was incubated with a nitrite concentration that can be found after a normal meal in the stomach at 37°C over 1 h. Reaction was started at pH 6.8–7.0 and stopped at pH 2.0, so we had the same pH change that occurs in the stomach. Secondly the genotoxic activities of drug-nitrite interaction products were tested by the umu-test with Salmonella typhimurium TA 1535/pSK1002 as tester strain in the presence and absence of metabolic activation. By the umu-test, among the nitrosation products of drugs examined 22 products showed genotoxicity at different levels. Other six products showed negative results by the umu-test. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG interactions
*NITRITES
*GENETIC toxicology
Subjects
Details
- Language :
- English
- ISSN :
- 01480545
- Volume :
- 26
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Drug & Chemical Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 10921342
- Full Text :
- https://doi.org/10.1081/DCT-120024844