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Na - ctl -2, a cDNA Encoding a C-type Lectin Expressed Exclusively in Adult Necator americanus Hookworms.
- Source :
-
DNA Sequence . Feb2002, Vol. 13 Issue 1, p61. 5p. - Publication Year :
- 2002
-
Abstract
- C-type lectins (C-TLs) are carbohydrate-binding proteins central to diverse physiological processes including immunity, venom-induced haemostasis and wound repair. Here we describe the cloning of Na - ctl -2, a cDNA encoding a secreted C-TL from the human hookworm Necator americanus . The transcript was detected in mRNA from adult worms but not infective larvae. The cDNA encoded an N-terminal secretory signal peptide followed by a long-form C-TL domain with sequence similarity to C-TL-like proteins from Caenorhabditis elegans and mammalian antigen presenting cell receptors, suggesting that hookworms might utilise this class of lectin to interrupt anti-parasite immune responses or interfere with host clotting mechanisms. This is the first report of a full-length cDNA encoding a lectin from hookworms. The unusually skewed representation of this protein family within different nematode genera and its subsequent impact on the evolution of nematode parasitism is discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NECATOR americanus
*LECTINS
Subjects
Details
- Language :
- English
- ISSN :
- 10425179
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- DNA Sequence
- Publication Type :
- Academic Journal
- Accession number :
- 10910720
- Full Text :
- https://doi.org/10.1080/10425170290019900