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New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation.
- Source :
-
Bioorganic & Medicinal Chemistry . Sep2015, Vol. 23 Issue 17, p6069-6077. 9p. - Publication Year :
- 2015
-
Abstract
- New acyloxy nitroso compounds, 4-nitrosotetrahydro-2 H -pyran-4-yl 2,2,2-trichloroacetate and 4-nitrosotetrahydro-2 H -pyran-4-yl 2,2-dichloropropanoate were prepared. These compounds release HNO under neutral conditions with half-lives between 50 and 120 min, identifying these HNO donors as kinetically intermediate to the much slower acetate derivative and the faster trifluoroacetic acid derivative. These compounds or HNO-derived from these compounds react with thiols, including glutathione, thiol-containing enzymes and heme-containing proteins in a similar fashion to other acyloxy nitroso compounds. HNO released from these acyloxy nitroso compounds inhibits activated platelet aggregation. These acyloxy nitroso compounds augment the range of release for this group of HNO donors and should be valuable tools in the further study of HNO biology. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 23
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 109106101
- Full Text :
- https://doi.org/10.1016/j.bmc.2015.04.023