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T-cell therapy targeting minor histocompatibility Ags for the treatment of leukemia and renal-cell carcinoma.

Authors :
Warren, EH
Tykodi, SS
Murata, M
Sandmaier, BM
Storb, R
Jaffee, E
Childs, R
Thompson, JA
Greenberg, PD
Riddell, SR
Source :
Cytotherapy (Taylor & Francis Ltd). Sep2002, Vol. 4 Issue 5, p441-441. 1p.
Publication Year :
2002

Abstract

Discusses research which evaluated the safety and anti-leukemic efficacy of adoptive T-cell therapy with CD8[sup +] cytotoxic T lymphocytes (CTL) clones specific for tissue-restricted minor histocompatibility (H) Ags, in patients with advanced myelodysplastic syndrome and acute leukemia who relapse after hematopoietic cell transplantation from an MHC-identical donor. Generation of the CTL clones; Observation on graft-versus-tumor effects.

Details

Language :
English
ISSN :
14653249
Volume :
4
Issue :
5
Database :
Academic Search Index
Journal :
Cytotherapy (Taylor & Francis Ltd)
Publication Type :
Academic Journal
Accession number :
10909679
Full Text :
https://doi.org/10.1080/146532402320776116