THE EFFECT OF LIME PEEL EXTRACT (Citrus Aurantifolia) TO TOTAL BLOOD CHOLESTEROL LEVELS OF MICE (Mus musculus) THAT GIVEN THE HIGH CHOLESTEROL DIET.

This article is to review existing research on the effects and potential of lemon peel as anticarcinogenesis. Lime peel contain flavonoid. Flavonoids are potent inhibitor of apoB secretion and inhibits the synthesis of cholesterol and triglycveride synthesis without affecting LDL receptor activity. Over a period of 35 days, the research used 30 male of mice (Mus musculus) as animal-test. 30 samples were divided into five groups with the six miceeach. The first group (control), given regular diet. The second group (negative control), given only high-fat diet. The third group, high-fat diet with ethanolic extract of lime peel 750 mg/kgBW and 0,5% CMC-Na solvent group. The fourth group, high-fat diet with ethanolic extract of lime peel 1500 mg/kgBW and 0,5% CMC-Na solvent group. The fifth group, high-fat diet with ethanolic extract of lime peel 2250 mg/kgBW and 0,5% CMC-Na solvent group. Total cholesterol in third group (high-fat diet with ethanolic extract of lime peel 750 mg/kgBW and 0,5% CMC-Na solvent) was higher than fourth group (high-fat diet with with ethanolic extract of lime peel 1500 mg/kgBW and 0,5% CMC-Na solvent). Total cholesterol in fifth group (high-fat diet with with ethanolic extract of lime peel 2250 mg/kgBW and 0,5% CMC-Na solven) is the lowest concentration group. According the results of research it can be concluded that the ethanolic extract of lime (Citrus aurantifolia) peel of 750 mg/kgBW, 1500 mg/kgBW, and 2250 mg/kgBW can't reduce total blood cholesterol of mice (Mus musculu). [ABSTRACT FROM AUTHOR]