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Amelioration of Auditory Response by DA9801 in Diabetic Mouse.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2015, p1-8. 8p. 1 Diagram, 2 Charts, 4 Graphs. - Publication Year :
- 2015
-
Abstract
- Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss. Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM. The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in enhancing these protective effects. We found a potential application of DA9801 on hearing impairment in the STZ-induced diabetic model, demonstrated by reducing the deterioration produced by DM in ABR threshold in response to clicks and normalizing wave I-IV latencies and Pa latencies in AMLR. We also show evidence that these effects might be elicited by inducing NGF related through Nr3c1 and Akt. Therefore, this result suggests that the neuroprotective effects of DA9801 on the auditory damage produced by DM may be affected by NGF increase resulting from Nr3c1 via Akt transformation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DEAFNESS prevention
*DIABETES complications
*ANIMAL experimentation
*AUDITORY perception testing
*BIOLOGICAL models
*CONFIDENCE intervals
*MICE
*POLYMERASE chain reaction
*RESEARCH funding
*STATISTICS
*WESTERN immunoblotting
*PLANT extracts
*DATA analysis
*TREATMENT effectiveness
*REPEATED measures design
*DATA analysis software
*ONE-way analysis of variance
THERAPEUTIC use of plant extracts
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 108824563
- Full Text :
- https://doi.org/10.1155/2015/230747