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Catalytic Methylation of C-H Bonds Using CO2 and H2.
- Source :
-
Angewandte Chemie International Edition . 9/22/2014, Vol. 53 Issue 39, p10476-10480. 5p. - Publication Year :
- 2014
-
Abstract
- Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H2 has been reported. Described herein is the combination of CO2 and H2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H2 system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBOXYLATION
*STOICHIOMETRY
*ORGANOMETALLIC chemistry
*METALS
*ELECTRONS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 53
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 108794881
- Full Text :
- https://doi.org/10.1002/anie.201405779