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Stakeholders' Views of Alternatives to Prospective Informed Consent for Minimal-Risk Pragmatic Comparative Effectiveness Trials.
- Source :
-
Journal of Law, Medicine & Ethics . Summer2015, Vol. 43 Issue 2, p397-409. 13p. 5 Charts. - Publication Year :
- 2015
-
Abstract
- As interest in comparative effectiveness research grows, questions have emerged regarding whether it is ever acceptable to alter informed consent requirements for research when patients are randomly assigned to widely-used therapies. This paper reports on interviews with Institutional Review Board members and researchers and on focus groups with patients from Geisinger and Johns Hopkins health systems. The objective was to elicit participants' views of the acceptability of four different disclosure and authorization models for low-risk pragmatic comparative effectiveness trials of widely-used therapies. Results suggest that although participants valued autonomous choice, many also believed that it was acceptable to streamline information disclosure and to use an opt-out process for eligible individuals who would prefer not to participate. This provides some preliminary evidence that relevant stakeholders find alternatives to traditional informed consent acceptable for low-risk pragmatic comparative effectiveness trials of widely-used therapies as long as a sufficient amount of choice is preserved. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFORMED consent (Medical law)
*STAKEHOLDERS
*INSTITUTIONAL review boards
*PATIENTS
*INTERVIEWING
*CLINICAL trials
*FOCUS groups
*ATTITUDE (Psychology)
*EMPLOYEES
*AUTONOMY (Psychology)
*COMPARATIVE studies
*DECISION making
*MANAGEMENT
*RESEARCH methodology
*CASE studies
*MEDICAL personnel
*MEDICAL research
*RESEARCH funding
*STATISTICAL sampling
*DISCLOSURE
*HUMAN research subjects
*PATIENT selection
Subjects
Details
- Language :
- English
- ISSN :
- 10731105
- Volume :
- 43
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Law, Medicine & Ethics
- Publication Type :
- Academic Journal
- Accession number :
- 108720222
- Full Text :
- https://doi.org/10.1111/jlme.12256